Plk4 cancer

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August undefined, 2024

Webb6 sep. 2024 · The critical role of centrosome amplification and PLK4 in cancer is summarized and recent advances in the development ofPLK4 inhibitors are highlighted, suggesting a potential therapeutic strategy for cancer. Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation … WebbDeregulated PLK4 activity plays a prominent role in cancer and metastasis. Several PLK4 inhibitors with anticancer activity are in pre-clinical stage and a single inhibitor, CFI-400945 has entered clinical phase. Further research should focus on finding safer and more effective drugs at clinical stage, based on a better understanding of PLK4.

Inhibition of Polo-like kinase 4 induces mitotic defects …

Webb25 mars 2024 · It is well known that PLK4 localizes to centrioles and coordinates duplication of centrioles in the late G1 and early S phases of the cell cycle. 9, 10 Increased PLK4 expression has been associated with poor outcomes in several human cancers, including colorectal, 11 breast, 12, 13 melanoma, 8 and neuroblastoma. 14 Proper … Webb1 jan. 2024 · Aberrated PLK4 expression has been reported in different malignancies and causes centrosome amplification, aneuploidy, and genomic instability. However, the … tierney\u0027s auto body hallstead pa

PLK4 Inhibitor Has Single-Agent Activity in Preclinical Tumor Models

WebbPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. PLK4 is not prognostic in prostate cancer. Alive (n=484) Webb3 aug. 2024 · Polo-like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. Webb12 mars 2024 · Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development. In this review, … the marriage of figaro song list

Expression of PLK4 in cancer - Summary - The Human Protein Atlas

Polo-Like Kinase 4

WebbPLK4 was also identified as a potential therapeutic target for malignant rhabdoid tumors, medulloblastomas and possibly, other embryonal tumors of the brain. Interactions and … WebbBackground: Our study aimed to investigate the association of polo-like kinase 4 (PLK4) expression with tumor features as well as survival in non-small cell lung cancer (NSCLC) … the marriage of figaro premiered inWebbTraductions en contexte de "thérapie et de diagnostic du cancer" en français-anglais avec Reverso Context : La présente invention a pour objet général de nouveaux composés phospholipides deutérés, des compositions comprenant ces composés, et leur utilisation dans diverses applications de thérapie et de diagnostic du cancer. tierney titus

"Webb1 dec. 2015 · 2.1. Elevated Plk4 expression dramatically advances the onset of tumour formation in p53-deficient mice. Centrosome amplification has been identified as a marker of poor prognosis of aggressive, drug-resistant tumours in breast, pancreatic and colorectal cancer patients [43,44], but the relationship of centriole amplification to … " - Plk4 cancer

Plk4 cancer

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Webb15 jan. 2024 · The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in advanced cancers based on increased expression in primary … Webb16 jan. 2024 · The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in advanced cancers based on increased expression in primary human …

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Webb6 sep. 2024 · Generally, PLK4 deregulation has clinical applications and the role of PLK4 as an oncogene or a tumor suppressor depends on the specific cancer type. PLK4 as a … WebbUncontrolled proliferation is one of the hallmarks of cancer. In this study, we analyzed the expression of the cell cycle-related genes receptor for hyaluronan (HA)-mediated motility …

WebbYLZ-F5, a novel polo-like kinase 4 inhibitor, inhibits human ovarian cancer cell growth by inducing apoptosis and mitotic defects Epub 2024 Jun 9. Authors Yongxia Zhu 1 , Zhihao … Webb1 jan. 2024 · TEC directly phosphorylates PLK4 at tyrosine 86 residue, which not only stabilizes the protein but also enhances PLK4-mediated HCC cell invasion. Further investigation by transcriptome sequencing indicated that PLK4 promotes the phosphorylation of focal adhesion kinase to regulate the focal adhesion pathway in HCC …

WebbIn addition, PLK4 was overexpressed in human PCa cell lines and tumors. Moreover, PLK4 inhibitors CFI-400945 and centrinone-B inhibited cell growth, viability, and colony … WebbMiR-654-3p Suppresses Non-Small Cell Lung Cancer Tumourigenesis by Inhibiting PLK4 . Fulltext; Metrics; Get Permission; Cite this article; Authors Pu J, Hu Z, Zhang D, Zhang T , He K, Dai T. Received 17 April 2024. Accepted for publication 25 July 2024

Webb24 maj 2024 · Polo-like kinase 4 (PLK4), a vital regulator of centriole duplication, is important for maintaining genome stability. Dysregulation of PLK4 has been found in several human cancers and is associated with a predisposition to tumorigenesis. Herein, we describe the discovery of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimi

WebbPolo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development … the marriage of figaro premiereWebbPLK4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … tierney\u0027s auto repairWebb24 nov. 2024 · Although the role of PLK4 has been studied in several cancers (37)(38) (39) (40), to narrow our scope for this review, we have focused on epithelial cancers. Although PLK4 has not been found to be ... tierney\\u0027s barWebb18 mars 2024 · Conclusions We show that by targeting a centrosome regulator, PLK4, to activate the cytosolic DNA sensing-mediated immune response, CFI-400945 effectively restrained tumor progression through cell cycle inhibition and inducing antitumor immunity to achieve a durable suppressive effect even in late-stage mouse HCC. CONFLICT OF … tierney\\u0027s bronxWebb10 apr. 2024 · PLK4 . Another potential drug class was developed with potential synergy with immunotherapy, according to Gautam Borthakur, MD, a Professor in the Department of Leukemia at the University of Texas MD Anderson Cancer Center. PLK4 is a novel target of interest in the management of leukemia. tierney tartanWebb15 juni 2024 · However, PLK4 has been shown to be dysregulated in certain cancers. Though the role of PLK4 in NMSC is not fully understood, we previously showed that PLK4 was significantly overexpressed in NMSC cell lines at both mRNA and protein levels as compared to normal keratinocytes, and its small molecule inhibition resulted in anti … tierney\\u0027s auto body hallstead paWebb15 juli 2013 · The Plk4 binding regions of Cep192 and Cep152 (residues 190–240 and 1–46, respectively) are rich in negatively charged amino acids, suggesting that Plk4 localization to centrioles depends on electrostatic interactions with the positively charged polo-box domain. tierney tax consultancy ltd