WebApr 11, 2012 · Follicular T-helper (T FH) cells cooperate with GL7 + CD95 + germinal center (GC) B cells to induce antibody maturation. Herein, we identify the transcription factor IRF4 as a T-cell intrinsic precondition for T FH cell differentiation and GC formation. After immunization with protein or infection with the protozoon Leishmania major, draining … WebApr 13, 2024 · IRF4-LBCL can display follicular, follicular and diffuse, or diffuse growth patterns and expresses, next to pan B-cell antigens, CD10, BCL2, and BCL6. Owing to the fusion, the IRF4 gene product MUM1 is strongly and uniformly expressed.
KSHV vIRF4 enhances BCL6 transcription via …
WebSep 19, 2024 · BCL6 functions as a transcriptional repressor that binds specific DNA sequences via its zinc fingers (ZFs) and recruits transcriptional co-repressor complexes by its BTB/POZ (Broad-Complex, Tramtrack, and Bric a brac [Zollman et al., 1994] or poxvirus and ZF [Bardwell and Treisman, 1994 ]) domain. WebJan 1, 2015 · Interferon regulatory factor 4 (IRF4) is a member of the IRF family of transcription factors that consists of 9 members. 9 IRF4 is expressed in most cell types of … corroborative evidence is used to
BCL6 (B-Cell Lymphoma 6) - atlasgeneticsoncology.org
WebFeb 19, 2024 · Ultimately, vIRF4 blocks the IRF4-mediated inhibition of BCL6 transcriptional activity, resulting in increased expression of BCL6 that contributes to efficient induction of … WebApr 9, 2024 · 在tb期间,t细胞而非b细胞中的转录因子irf4是产生辅助t细胞的t h 1和t h 17亚群以及卵泡辅助t(t fh )样细胞反应所必需的。 在 Mtb 感染期间,IRF4 + T细胞群共表达转录因子BCL6,CD4 + T细胞(CD4 cre )中BCL6(Bcl6 fl/fl )的缺失导致T FH 样细胞减少,GrALT内的定位受损 ... WebBCL6 Fusion is present in 0.13% of AACR GENIE cases, with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, bladder urothelial carcinoma, lung … corroboration warning