Cisplatin adducts

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August undefined, 2024

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, … WebThe DNA adducts of cisplatin are thought to mediate its cytotoxic effects by inhibiting DNA replication and transcription and, ultimately, by inducing programmed cell death, or …

Cisplatin intrastrand adducts sensitize DNA to base damage by

WebIn nDNA, cisplatin-DNA adducts are removed and DNA is repaired by nucleotide excision repair (NER). Mitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting with purine bases, activating several signal transduction pathways, and silencing or activating several genes which finally leads to apoptosis. eigenvalues in statistics

Cisplatin DNA damage and repair maps of the human genome at …

WebHuman colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins These results indicate that high-level resistance of human colon cancer cells to high doses of cisplatin and oxaliplatin does not seem to be related to acquired defects in the DNA MMR proteins. WebJul 18, 2007 · One potential predictive marker is the formation of cisplatin-DNA adducts, which are formed when cisplatin reacts with the cellular DNA by binding to nucleotides. … WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel … follow the fleet

Cisplatin - Group 10: platinum anticancer agents - Pharmacy 180

Oleuropein Ameliorates Cisplatin-induced Hematological …

WebThe cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of … WebThis mixture is heated from 20^ {\circ} \mathrm {C} 20∘C to 200^ {\circ} \mathrm {C} 200∘C while flowing through a tube in which the pressure is maintained at 150 kPa. Determine the heat transfer to the mixture per unit mass of the mixture. Verified answer. physics. A 32.0-\Omega 32.0−Ω resistance coil uses 375 \mathrm {~W} 375 W of power. eigenvalues in vibration analysisWebThese covalent adducts are formed by linking the 3, 4 ( pyrone) or 4', 5’ ( furan) edge of psoralen to the 5, 6 double bond of thymine. Psoralens can form two types of monoadducts and one diadduct (an interstrand crosslink) with thymine. [10] These adducts result in local distortions to DNA at the site of intercalation. eigenvalues math is fun

"WebCisplatin is mainly eliminated via urine. The highest concentrations can be found in the liver, prostate and kidneys. Side effects include severe nausea, vomiting, ototoxicity and nephrotoxicity, together with myelosuppression (bone marrow suppression). " - Cisplatin adducts

Cisplatin adducts

Recognition and processing of cisplatin- and oxaliplatin-DNA adducts

WebCisplatin is an effective, widely used drug for many cancers, which shows a high level and broad spectrum of antitumor activities. (1−6) It has been known that the binding between this drug molecule and the DNA molecule disables the physiologic activities of DNA and eventually induces cell apoptosis. WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …

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WebApr 9, 1999 · Cisplatin is well known as a DNA-damaging agent, and the specific adducts produced in DNA have been well characterized. However, the mechanism by which … WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response …

WebFORMATION OF CISPLATIN: (NH4)2[PtCl6] hn H3N H3N Pt Cl Cl cisplatin • 1965年，Barnett Rosenberg发现了顺铂有抗癌活性 • 1978年，顺铂被批准作为抗癌药 A pair of history-making compounds H3N H3N Pt Cl Cl NH3 Pt Cl H3N Transplatin Cl Cisplatin 1845 Synthesis - Peyrone's Chloride. 1893 Structure deduced by Alfred Werner.

WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We … WebMay 8, 2014 · The masses of the platinum adducts following digestion and separation by HPLC were measured by mass spectrometry. Our results demonstrate that hydrated …

WebOct 23, 2003 · Cisplatin is a neutral inorganic, square planar complex that reacts with DNA to induce its characteristic biological effects, which culminate in either repair of the DNA damage and cell survival...

WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … eigenvalues of 2 by 2WebThe cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of adducts at the same sites on DNA. However, the DNA adducts are differentially recognized by a number of cellular proteins … follow the fleet - 1936WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. eigenvalues numerical methodsWebMay 7, 2024 · The formation of adducts between cisplatin and nuclear DNA is not the only mechanism by which cisplatin induces cytotoxicity, and cisplatin also has significant toxicity to enucleated cells.[6 7] Some studies have shown that oxidative stress is related to cisplatin-induced cytotoxicity, and cisplatin induces intracellular reactive oxygen ... follow the fleet 1936WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … eigenvalues of 3x3WebThe synthesis and characterisation of novel metal-modified DNA precursors for fuel cell catalyst development are described. Material precursors in the form of metal–DNA … eigenvalues of 1x1 matrixWebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by … follow the fleet 1936 movie